H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts.

ABSTRACT:

Background

H3K27ac histone acetylome changes contribute to the phenotypic response in heart diseases, particularly in end-stage heart failure. However, such epigenetic alterations have not been systematically investigated in remodeled non-failing human hearts. Therefore, valuable insight into cardiac dysfunction in early remodeling is lacking. This study aimed to reveal the acetylation changes of chromatin regions in response to myocardial remodeling and their correlations to transcriptional changes of neighboring genes.

Results

We detected chromatin regions with differential acetylation activity (DARs; P_adj. < 0.05) between remodeled non-failing patient hearts and healthy donor hearts. The acetylation level of the chromatin region correlated with its RNA polymera

SUBMITTER: Pei J 

PROVIDER: S-EPMC7362435 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature