Nasal microbiota dominated by Moraxella spp. is associated with respiratory health in the elderly population: a case control study.

ABSTRACT:

Background

The elderly (≥65 years) are one of the populations most at risk for respiratory tract infections (RTIs). The aim of this study was to determine whether nasal and/or oropharyngeal microbiota profiles are associated with age and RTIs.

Methods

Nasal and oropharyngeal swabs of 152 controls and 152 patients with an RTI were included. The latter group consisted of 72 patients with an upper respiratory tract infection (URTI) and 80 with a lower respiratory tract infection (LRTI). Both nasal and oropharyngeal swabs were subjected to microbiota profiling using amplicon sequencing of the 16S rRNA gene. Moraxella species were determined using quantitative real-time PCR and culture.

Results

Based on the microbiota profiles of the controls and the patients with an RTI,

SUBMITTER: van den Munckhof EHA 

PROVIDER: S-EPMC7362441 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature