De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture.

ABSTRACT:

Background

Resveratrol is a plant secondary metabolite with diverse, potential health-promoting benefits. Due to its nutraceutical merit, bioproduction of resveratrol via microbial engineering has gained increasing attention and provides an alternative to unsustainable chemical synthesis and straight extraction from plants. However, many studies on microbial resveratrol production were implemented with the addition of water-insoluble phenylalanine or tyrosine-based precursors to the medium, limiting in the sustainable development of bioproduction.

Results

Here we present a novel coculture platform where two distinct metabolic background species were modularly engineered for the combined total and de novo biosynthesis of resveratrol. In this scenario, the upstream Escherichia

SUBMITTER: Yuan SF 

PROVIDER: S-EPMC7362445 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature