Oral delivery of insulin with intelligent glucose-responsive switch for blood glucose regulation.

ABSTRACT:

Background

The traditional treatment for diabetes usually requires frequent insulin injections to maintain normoglycemia, which is painful and difficult to achieve blood glucose control.

Results

To solve these problems, a non-invasive and painless oral delivery nanoparticle system with bioadhesive ability was developed by amphipathic 2-nitroimidazole-L-cysteine-alginate (NI-CYS-ALG) conjugates. Moreover, in order to enhance blood glucose regulation, an intelligent glucose-responsive switch in this nanoparticle system was achieved by loading with insulin and glucose oxidase (GOx) which could supply a stimulus-sensitive turnover strategy. In vitro tests illustrated that the insulin release behavior was switched "ON" in response to hyperglycemic state by GOx catalysis and "OFF"

SUBMITTER: Zhou X 

PROVIDER: S-EPMC7362448 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature