Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana.

ABSTRACT:

Background

Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome. Mutations in pfmdr1 gene is linked to reduced parasite susceptibility to amodiaquine and lumefantrine. In addition, the potency of the partner drugs in vivo depends on the metabolism by the cytochrome P450 (CYP) enzyme in the host. Mutations in the CYP2C8 and CYP3A4 genes are linked to reduced metabolism of amodiaquine and lumefantrine in vitro, respectively. This study investigated the host and parasite genetic factors affecting the susceptibility of the malaria parasite to ACT partner drugs.

Methods

Archived samples from 240

SUBMITTER: Hodoameda P 

PROVIDER: S-EPMC7362516 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature