C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.

ABSTRACT: Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that survive within tissue cysts. Activation of the innate immune system is critical during the early phase of infection to limit pathogen growth and to instruct parasite-specific adaptive immunity. In rodents, dendritic cells (DCs) sense T. gondii through TLR11/12, leading to IL-12 production, which activates NK cells to produce IFN-γ as an essential mechanism for early parasite control. Further, C3 can bind to T. gondii resulting in limited complement activation. Here, we determined the role of C5a/C5aR1 axis activation for the ear

SUBMITTER: Briukhovetska D 

PROVIDER: S-EPMC7362728 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature