High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes.

ABSTRACT: Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic molecular marker in colorectal cancer (CRC) using immunohistochemical and transcriptomic data. FAP expression and clinicopathological information were obtained from The Cancer Genome Atlas data set. The association of FAP expression and tissue cellular heterogeneity landscape was explored using the xCell method. We evaluated FAP protein expression in a cohort of 92 CRCs and 19 non-tumoral tissues. We observed that FAP was upregulated in tumors both at the mRNA and protein levels, and its expression was associated with advanced stages, poor survival, and consensus molecular subtype 4. FAP

SUBMITTER: Coto-Llerena M 

PROVIDER: S-EPMC7362758 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature