Early transmission of sensitive strain slows down emergence of drug resistance in Plasmodium vivax.

ABSTRACT: The spread of drug resistance of Plasmodium falciparum and Plasmodium vivax parasites is a challenge towards malaria elimination. P. falciparum has shown an early and severe drug resistance in comparison to P. vivax in various countries. In fact, P. vivax differs in its life cycle and treatment in various factors: development and duration of sexual parasite forms differ, symptoms severity are unequal, relapses present only in P. vivax cases and the Artemisinin-based combination therapy (ACT) is only mandatory in P. falciparum cases. We compared the spread of drug resistance for both species through two compartmental models using ordinary differential equations. The model structure describes how sensitive and resistant parasite strains infect a human population treated with antimalarials. W

SUBMITTER: Ayala MJC 

PROVIDER: S-EPMC7363008 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature