Differential epigenetic factors in the prediction of cardiovascular risk in diabetic patients.

ABSTRACT: Hyperglycaemia can strongly alter the epigenetic signatures in many types of human vascular cells providing persistent perturbations of protein-protein interactions both in micro- and macro-domains. The establishment of these epigenetic changes may precede cardiovascular (CV) complications and help us to predict vascular lesions in diabetic patients. Importantly, these epigenetic marks may be transmitted across several generations (transgenerational effect) and increase the individual risk of disease. Aberrant DNA methylation and imbalance of histone modifications, mainly acetylation and methylation of H3, represent key determinants of vascular lesions and, thus, putative useful biomarkers for prevention and diagnosis of CV risk in diabetics. Moreover, a differential expression of some mic

SUBMITTER: Napoli C 

PROVIDER: S-EPMC7363021 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature