A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C.

ABSTRACT: Rabies, caused by RNA viruses in the Genus Lyssavirus, is the most fatal of all infectious diseases. This neglected zoonosis remains a major public health problem in developing countries, causing the death of an estimated 25,000-159,000 people each year, with more than half of them in children. The high incidence of human rabies in spite of effective vaccines is mainly linked to the lack of compliance with the complicated administration schedule, inadequacies of the community public health system for local administration by the parenteral route and the overall costs of the vaccine. The goal of our work was the development of a simple, affordable and effective vaccine strategy to prevent human rabies virus infection. This next generation vaccine is based on a replication-defective chimpanze

SUBMITTER: Napolitano F 

PROVIDER: S-EPMC7363076 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature