Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infection.

ABSTRACT: Viral infection outcomes are governed by the complex and dynamic interplay between the infecting virus population and the host response. It is increasingly clear that both viral and host cell populations are highly heterogeneous, but little is known about how this heterogeneity influences infection dynamics or viral pathogenicity. To dissect the interactions between influenza A virus (IAV) and host cell heterogeneity, we examined the combined host and viral transcriptomes of thousands of individual cells, each infected with a single IAV virion. We observed complex patterns of viral gene expression and the existence of multiple distinct host transcriptional responses to infection at the single cell level. We show that human H1N1 and H3N2 strains differ significantly in patterns of both vira

SUBMITTER: Sun J 

PROVIDER: S-EPMC7363107 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature