The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex.

ABSTRACT: Specialized transporting and sensory epithelial cells employ homologous protocadherin-based adhesion complexes to remodel their apical membrane protrusions into organized functional arrays. Within the intestine, the nutrient-transporting enterocytes utilize the intermicrovillar adhesion complex (IMAC) to assemble their apical microvilli into an ordered brush border. The IMAC bears remarkable homology to the Usher complex, whose disruption results in the sensory disorder type 1 Usher syndrome (USH1). However, the entire complement of proteins that comprise both the IMAC and Usher complex are not yet fully elucidated. Using a protein isolation strategy to recover the IMAC, we have identified the small EF-hand protein calmodulin-like protein 4 (CALML4) as an IMAC component. Consistent with th

SUBMITTER: Choi MS 

PROVIDER: S-EPMC7363140 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature