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5-HT_2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression.

ABSTRACT: Background: Acute treatment with the selective serotonin reuptake inhibitor (SSRI), fluoxetine (Flx), induces anxiety-like behavioral effects. The serotonin_2A receptor (5-HT_2A) is implicated in the modulation of anxiety-like behavior, however its contribution to the anxiogenic effects of acute Flx remains unclear. Here, we examined the role of the 5-HT_2A receptor in the effects of acute Flx on anxiety-like behavior, serum corticosterone levels, neural activation and immediate early gene (IEG) expression in stress-responsive brain regions, using 5-HT_2A receptor knockout (5-HT_2A ^-/-) mice of both sexes. Methods: 5-HT_2A ^-/- and wild-type (WT) male and female mice received a single administrat

SUBMITTER: Jaggar M

PROVIDER: S-EPMC7363295 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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5-HT_2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

5-HT2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression.

OmicsDI is part of the ELIXIR infrastructure

Tweets

5-HT_2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression.