Cortical cells are altered by factors including bone morphogenetic protein released from a placental barrier model under altered oxygenation.

ABSTRACT: Episodes of hypoxia and hypoxia/reoxygenation during foetal development have been associated with increased risk of neurodevelopmental conditions presenting in later life. The mechanism for this is not understood; however, several authors have suggested that the placenta plays an important role. Previously we found both placentas from a maternal hypoxia model and pre-eclamptic placentas from patients release factors lead to a loss of dendrite complexity in rodent neurons. Here to further explore the nature and origin of these secretions we exposed a simple in vitro model of the placental barrier, consisting of a barrier of human cytotrophoblasts, to hypoxia or hypoxia/reoxygenation. We then exposed cortical cultures from embryonic rat brains to the conditioned media (CM) from below

SUBMITTER: Leinster VHL 

PROVIDER: S-EPMC7363303 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature