Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease.

ABSTRACT: Prenatal development is a critical period for programming of neurological disease. Preeclampsia, a pregnancy complication involving oxidative stress in the placenta, has been associated with long-term health implications for the child, including an increased risk of developing schizophrenia and autism spectrum disorders in later life. To investigate if molecules released by the placenta may be important mediators in foetal programming of the brain, we analysed if placental tissue delivered from patients with preeclampsia secreted molecules that could affect cortical cells in culture. Application of culture medium conditioned by preeclamptic placentae to mixed cortical cultures caused changes in neurons and astrocytes that were related to key changes observed in brains of patients with schi

SUBMITTER: Scott H 

PROVIDER: S-EPMC7363326 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature