Acute kidney injury and maladaptive tubular repair leading to renal fibrosis.

ABSTRACT:

Purpose of review

Despite improvements in acute kidney injury (AKI) detection, therapeutic options to halt the progression of AKI to chronic kidney disease (CKD) remain limited. In this review, we focus on recent discoveries related to the pathophysiology of the AKI to CKD continuum, particularly involving the renal tubular epithelial cells, and also discuss related ongoing clinical trials. While our focus is on injured renal tubular epithelial cells as initiators of the cascade of events resulting in paracrine effects on other cells of the kidney, the summation of maladaptive responses from various kidney cell types ultimately leads to fibrosis and dysfunction characteristic of CKD.

Recent findings

Recent findings that we will focus on include, but are not limited to, chara

SUBMITTER: Yu SM 

PROVIDER: S-EPMC7363449 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature