Post-stroke deficit prediction from lesion and indirect structural and functional disconnection.

ABSTRACT: Behavioural deficits in stroke reflect both structural damage at the site of injury, and widespread network dysfunction caused by structural, functional, and metabolic disconnection. Two recent methods allow for the estimation of structural and functional disconnection from clinical structural imaging. This is achieved by embedding a patient's lesion into an atlas of functional and structural connections in healthy subjects, and deriving the ensemble of structural and functional connections that pass through the lesion, thus indirectly estimating its impact on the whole brain connectome. This indirect assessment of network dysfunction is more readily available than direct measures of functional and structural connectivity obtained with functional and diffusion MRI, respectively, and it is

SUBMITTER: Salvalaggio A 

PROVIDER: S-EPMC7363494 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature