Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic whose etiology reflects multiple interactions between environmental and genetic factors. Here, we review the major pathways and dominant genetic modifiers known to be relevant players in human NAFLD and which may determine key components of the heritability of distinctive disease traits including steatosis and fibrosis. In addition, we have employed general assumptions which are based on known genetic factors in NAFLD to build a systems biology prediction model that includes functional enrichment. This prediction model highlights additional complementary pathways that represent plausible intersecting signaling networks that we define here as an NAFLD-Reactome. We review the evidence connecting variants in e

SUBMITTER: Sookoian S 

PROVIDER: S-EPMC7363530 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature