Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a^+/- Mice.

ABSTRACT:

Background

A breakdown of synchrony within neuronal ensembles leading to destabilization of network "attractors" could be a defining aspect of neuropsychiatric diseases such as schizophrenia, representing a common downstream convergence point for the diverse etiological pathways associated with the disease. Using a mouse genetic model, we demonstrated that altered ensembles are associated with pathological sensory cortical processing phenotypes resulting from loss of function mutations in the Setd1a gene, a recently identified rare risk genotype with very high penetrance for schizophrenia.

Methods

We used fast two-photon calcium imaging of neuronal populations (calcium indicator GCaMP6s, 10 Hz, 100-250 cells, layer 2/3 of primary visual cortex, i.e., V1) in awake head-fixed

SUBMITTER: Hamm JP 

PROVIDER: S-EPMC7363535 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature