Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.

ABSTRACT:

Purpose of review

Traditional methods to assess antiretroviral adherence, such as self-report, pill counts, and pharmacy refill data, may be inaccurate in determining actual pill-taking to both antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP). HIV viral loads serve as surrogates of adherence on ART, but loss of virologic control may occur well after decreases in adherence and viral loads are not relevant to PrEP.

Recent findings

Pharmacologic measures of adherence, electronic adherence monitors, and ingestible electronic pills all serve as more objective metrics of adherence, surpassing self-report in predicting outcomes. Pharmacologic metrics can identify either recent adherence or cumulative adherence. Recent dosing measures include antiretroviral levels in

SUBMITTER: Spinelli MA 

PROVIDER: S-EPMC7363551 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature