Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis.

ABSTRACT:

Objectives

Identifying the interplay between socioeconomic markers (education and financial resources) and polygenetic predisposition influencing the time of dementia and the diagnosis of clinical Alzheimer's disease (AD) dementia is of central relevance for preventive strategies.

Design

Prospective cohort design.

Setting

The English Longitudinal Study of Aging is a household survey data set of a representative sample.

Participants

A total of 7,039 individuals aged 50 years and older participated in the study. Of these, 320 (4.6%) were diagnosed with dementia over the 10-year follow-up.

Measurements

Polygenic score (PGS) for Alzheimer's disease (AD-PGS) was calculated using summary statistics from the International Genomics of Alzheimer's Project. An acc

SUBMITTER: Ajnakina O 

PROVIDER: S-EPMC7363562 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature