Perinatal stabilisation of infants born with congenital diaphragmatic hernia: a review of current concepts.

ABSTRACT: Congenital diaphragmatic hernia (CDH) is associated with high mortality rates and significant pulmonary morbidity, mainly due to disrupted lung development related to herniation of abdominal organs into the chest. Pulmonary hypertension is a major contributor to both mortality and morbidity, however, treatment modalities are limited. Novel prenatal and postnatal interventions, such as fetal surgery and medical treatments, are currently under investigation. Until now, the perinatal stabilisation period immediately after birth has been relatively overlooked, although optimising support in these early stages may be vital in improving outcomes. Moreover, physiological parameters obtained from the perinatal stabilisation period could serve as early predictors of adverse outcomes, thereby facili

SUBMITTER: Horn-Oudshoorn EJJ 

PROVIDER: S-EPMC7363792 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature