Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells.

ABSTRACT: More than 94% of colorectal cancer cases have mutations in one or more Wnt/β-catenin signaling pathway components. Inactivating mutations in APC or activating mutations in β-catenin (CTNNB1) lead to signaling overactivation and subsequent intestinal hyperplasia. Numerous classes of medicines derived from synthetic or natural small molecules, including alkaloids, have benefited the treatment of different diseases, including cancer, Piperine is a true alkaloid, derived from lysine, responsible for the spicy taste of black pepper (Piper nigrum) and long pepper (Piper longum). Studies have shown that piperine has a wide range of pharmacological properties; however, piperine molecular mechanisms of action are still not fully understood. By using Wnt/β-catenin pathway epistasis experiment we sho

SUBMITTER: de Almeida GC 

PROVIDER: S-EPMC7363889 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature