Increased anticipatory brain response to pleasant touch in women remitted from bulimia nervosa.

ABSTRACT: Bulimia nervosa (BN) is characterized by affective instability and dysregulated behaviors (binge eating, fasting, self-induced vomiting) that disrupt bodily homeostasis. Mechanisms underlying dysregulation in BN are unclear, although altered reward responsivity, anticipatory processing of environmental cues, and interoception (detection and integration of body-state signals to regulate behavior) have been implicated in BN pathophysiology. We aimed to determine whether BN is associated with ineffectively predicting body state or integrating predicted experience with actual experience by examining neural response to anticipation and experience of affective touch, a pleasant interoceptive stimulus that acts on sensory and emotional systems to guide behavior. During fMRI, we administered soft

SUBMITTER: Wierenga CE 

PROVIDER: S-EPMC7363900 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature