Immune checkpoints bone marrow expression as the predictor of clinical outcome in myelodysplastic syndrome.

ABSTRACT:

Aims

In our single-center retrospective study we evaluated whether level of different checkpoint molecules in bone marrow biopsies at diagnosis affect the clinical course of patients with myelodysplastic syndrome (MDS).

Methods and results

A consecutive cohort of 55 MDS patients treated in our center from 2003 to 2018 with available bone marrow biopsies at time of diagnosis was studied. We used a technique able to detect the expression of the following antigens: PD-1, PD-L1, PD-L2, LAG-3, Gal-9, TIM-3, CD80. The association between expression level and 3-year overall and relapse-free survival and time-to-progression was analyzed. Intensive expression of TIM-3 was observed in 100% of cases. Also, in most cases, moderate Gal-9 expression was observed. With 3-year follow-up dis

SUBMITTER: Tcvetkov N 

PROVIDER: S-EPMC7364161 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature