Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation.

ABSTRACT:

Background & aims

Hypothermic oxygenated machine perfusion (HOPE) is a promising technique for providing oxygen to the liver during graft preservation; however, because of associated logistical constraints, addition of an oxygen transporter to static cold-storage solutions (SCS) might be easier. M101 is marine worm haemoglobin that has been shown to improve kidney preservation in the clinic when added to SCS. This study evaluated the effects of the addition of M101 to SCS on the quality of pig liver graft preservation.

Methods

Pig liver grafts were preserved using SCS, HOPE, or SCS+M101, and the liver functions were compared during cold preservation and after orthotopic allotransplantation (OLT) in pigs.

Results

During preservation of the liver grafts, mitochondrial f

SUBMITTER: Alix P 

PROVIDER: S-EPMC7364164 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature