Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.

ABSTRACT:

Purpose

Detection of bacteria-specific metabolism via positron emission tomography (PET) is an emerging strategy to image human pathogens, with dramatic implications for clinical practice. In silico and in vitro screening tools have recently been applied to this problem, with several monosaccharides including l-arabinose showing rapid accumulation in Escherichia coli and other organisms. Our goal for this study was to evaluate several synthetically viable arabinofuranose-derived ¹⁸ F analogs for their incorporation into pathogenic bacteria.

Procedures

We synthesized four radiolabeled arabinofuranose-derived sugars: 2-deoxy-2-[¹⁸ F]fluoro-arabinofuranoses (d-2-¹⁸ F-AF and l-2-¹⁸ F-AF) and 5-deoxy-5-[¹⁸ F]fluoro-arabinofur

SUBMITTER: Kalita M 

PROVIDER: S-EPMC7364301 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature