High Enantiomeric Excess In-Loop Synthesis of d-[methyl-¹¹C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.

ABSTRACT: Currently, there exists no accurate, noninvasive clinical imaging method to detect living bacteria in vivo. Our goal is to provide a positron emission tomography (PET) method to image infection by targeting bacteria-specific metabolism. Standard of care methodologies detect morphologic changes, image immunologic response to infection, or employ invasive tissue sampling with associated patient morbidity. These strategies, however, are not specific for living bacteria and are often inadequate to detect bacterial infection during fever workup. As such, there is an unmet clinical need to identify and validate new imaging tools suitable for noninvasive, in vivo (PET) imaging of living bacteria. We have shown that d-[methyl-¹¹C]methionine (d-[¹¹C]Met) can dist

SUBMITTER: Stewart MN 

PROVIDER: S-EPMC7364312 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature