Multitargeting Antibacterial Activity of a Synthesized Mn²⁺ Complex of Curcumin on Gram-Positive and Gram-Negative Bacterial Strains.

ABSTRACT: Curcumin is an important molecule with a plethora of pharmacological activities and therapeutic potentials. Despite its efficacy, it remained a potential drug candidate owing to hydrolytic instability and poor aqueous solubility. To overcome the limitations related to low solubility, low bioavailability, and the fact that curcumin is never present in solution as a "single unit", its complex was prepared with Mn^II with the idea that binding to a metal ion might help to resolve these issues. The complex was characterized by elemental and spectral analysis. The structure of the complex was determined by density functional theory calculations. The complex was stable at physiological buffer conditions, unlike curcumin. It did not have any detrimental effect on mammalian cells. There

SUBMITTER: Saha T 

PROVIDER: S-EPMC7364437 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature