Super-resolution Surface-Enhanced Raman Scattering Imaging of Single Particles in Cells.

ABSTRACT: The ability to locate and identify molecular interactions in cells has significant importance for understanding protein function and molecular biology. Functionalized metallic nanoparticles have been used as probes for protein tracking and drug delivery because of their ability to carry therapeutic agents and readily functionalized surfaces. In this work, we present a super-resolution surface-enhanced Raman scattering (SERS) approach for imaging and tracking membrane receptors interacting with peptide-functionalized gold nanostars (AuNS). The α_vβ₃ integrin receptors in colon cancer cells are successfully targeted and imaged using AuNS with the high-affinity amino acid sequence arginine-glycine-aspartic acid-phenylalanine-cysteine (RGDFC) attached. The RGDFC peptide in

SUBMITTER: de Albuquerque CDL 

PROVIDER: S-EPMC7364441 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature