Genome-wide characterization of copy number variations in the host genome in genetic resistance to Marek's disease using next generation sequencing.

ABSTRACT:

Background

Marek's disease (MD) is a highly neoplastic disease primarily affecting chickens, and remains as a chronic infectious disease that threatens the poultry industry. Copy number variation (CNV) has been examined in many species and is recognized as a major source of genetic variation that directly contributes to phenotypic variation such as resistance to infectious diseases. Two highly inbred chicken lines, 6₃ (MD-resistant) and 7₂ (MD-susceptible), as well as their F₁ generation and six recombinant congenic strains (RCSs) with varied susceptibility to MD, are considered as ideal models to identify the complex mechanisms of genetic and molecular resistance to MD.

Results

In the present study, to unravel the potential genetic mechanism

SUBMITTER: Bai H 

PROVIDER: S-EPMC7364486 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature