Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. The aim of our study was to describe the pathological changes in menisci and ligament during disease development in murine spontaneous and post-traumatic surgically induced OA and to quantify tissue mineralisation in the joint space using micro-computed tomography (μCT) imaging during OA progression.

Methods

Knees of Str/ort mice (spontaneous OA model; 26-40 weeks) and C57CBA F1 mice following destabilisation of medial meniscus (DMM) surgery (post-traumatic OA m

SUBMITTER: Ramos-Mucci L 

PROVIDER: S-EPMC7364489 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature