Polygenic analysis of very high acetic acid tolerance in the yeast Saccharomyces cerevisiae reveals a complex genetic background and several new causative alleles.

ABSTRACT:

Background

High acetic acid tolerance is of major importance in industrial yeast strains used for second-generation bioethanol production, because of the high acetic acid content of lignocellulose hydrolysates. It is also important in first-generation starch hydrolysates and in sourdoughs containing significant acetic acid levels. We have previously identified snf4 ^E269* as a causative allele in strain MS164 obtained after whole-genome (WG) transformation and selection for improved acetic acid tolerance.

Results

We have now performed polygenic analysis with the same WG transformant MS164 to identify novel causative alleles interacting with snf4 ^E269* to further enhance acetic acid tolerance, from a range of 0.8-1.2% acetic ac

SUBMITTER: Stojiljkovic M 

PROVIDER: S-EPMC7364526 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature