Lipidomics profiling of skin surface lipids in senile pruritus.

ABSTRACT:

Background

Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipid (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus.

Methods

Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations.

Results

The results showed that senile pruritus patients had higher TEWL values than con

SUBMITTER: Ma X 

PROVIDER: S-EPMC7364579 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature