Nociceptin is present in synovial fluid of patients undergoing total knee arthroplasty.

ABSTRACT:

Background

Osteoarthritis is a mechanical abnormality characterized by chronic joint pain associated with degeneration of the articular cartilage, synovitis, and local inflammation, leading to loss of function and pain. A connection exists between the peripheral nervous system and inflammatory joint degeneration. The process by which inflammation is influenced by the nervous system is known as neuroinflammation. One of the neuropeptides involved in peripheral neuroinflammation is nociceptin, a peptide related to the opioid class of substances. Nociceptin has both pro- and anti-inflammatory effects. Some studies show that nociceptin can be measured in synovial fluid, while other studies have not been able to detect it. The presence of nociceptin in synovial fluid could imply a molec

SUBMITTER: Verbeek TA 

PROVIDER: S-EPMC7364622 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature