Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration.

ABSTRACT:

Background

Disturbed sleep is associated with cognitive decline in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). The progressive sequence of how neurodegeneration affects aspects of sleep architecture in conjunction with behavioural changes is not well understood.

Methods

We investigated changes in sleep architecture, spectral power and circadian rhythmicity in the tet-off rTg4510 mouse overexpressing human P301L tau within the same subjects over time. Doxycycline-induced transgene-suppressed rTg4510 mice, tTa carriers and wild-type mice were used as comparators. Spectral power and sleep stages were measured from within the home cage environment using EEG electrodes. In addition, locomotor activity and performance during a T-m

SUBMITTER: Holton CM 

PROVIDER: S-EPMC7364634 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature