Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort.

ABSTRACT:

Background

Serum creatinine (Cr) and cystatin C (CysC) can both be used to estimate glomerular filtration rate (eGFR_Cr and eGFR_CysC). However, certain conditions may cause discrepancies between eGFR trends from Cr and CysC, and these remain undetermined in patients with chronic kidney disease (CKD).

Methods

A total of 1069 patients from the Korean CKD cohort (KNOW-CKD), which enrolls pre-dialytic CKD patients, whose Cr and CysC had been followed for more than 4 years were included in the sample. We performed trajectory analysis using latent class mixed modeling and identified members of the discrepancy group when patient trends between eGFR_Cr and eGFR_CysC differed. Multivariate logistic analyses with Firth's penalized likelihood re

SUBMITTER: Kang E 

PROVIDER: S-EPMC7364655 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature