Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability.

ABSTRACT: Despite important efforts to solve the clinico-radiological paradox, correlation between lesion load and physical disability in patients with multiple sclerosis remains modest. One hypothesis could be that lesion location in corticospinal tracts plays a key role in explaining motor impairment. In this study, we describe the distribution of lesions along the corticospinal tracts from the cortex to the cervical spinal cord in patients with various disease phenotypes and disability status. We also assess the link between lesion load and location within corticospinal tracts, and disability at baseline and 2-year follow-up. We retrospectively included 290 patients (22 clinically isolated syndrome, 198 relapsing remitting, 39 secondary progressive, 31 primary progressive multiple sclerosis) from

SUBMITTER: Kerbrat A 

PROVIDER: S-EPMC7364770 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature