Effects of Nicotine Metabolic Rate on Cigarette Reinforcement.

ABSTRACT: INTRODUCTION:The rate of nicotine metabolism, estimated by the nicotine metabolite ratio (NMR), is an important determinant of tobacco dependence. This study investigated the effect of NMR on smoking behavior due to nicotine reinforcement during ad libitum smoking. AIMS AND METHODS:As part of a larger study, participants were stratified based on saliva NMR as fast and slow metabolizers. After smoking a cigarette and measuring nicotine blood concentrations, participants smoked as desired over a 90-minute period. Analysis included time to first cigarette, total number of cigarettes, total number of puffs, and weight of tobacco consumed. RESULTS:Sixty-one (48%) participants were fast metabolizers and 66 (52%) slow metabolizers by NMR. No significant differences were found regarding the smokin

SUBMITTER: Liakoni E 

PROVIDER: S-EPMC7364822 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature