Cigarette smoke inhalation aggravates diabetic kidney injury in rats.

ABSTRACT: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Epidemiological studies have demonstrated that cigarette smoke or nicotine is a risk factor for the progression of chronic kidney injury. The present study analyzed the kidney toxicity of cigarette smoke in experimental rats with DKD. Experimental diabetes was induced in 7-week-old Sprague-Dawley rats by a single intraperitoneal injection of streptozotocin (60 mg kg^-1). Four weeks after the induction of diabetes, rats were exposed to cigarette smoke (200 μg L^-1), 4 h daily, and 5 days per week for 4 weeks. Cigarette smoke did not affect the levels of plasma glucose, hemoglobin A1c, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol or non-esterified fatty acids in bo

SUBMITTER: Jiang S 

PROVIDER: S-EPMC7364853 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature