Reduced cortical thickness in World Trade Center responders with cognitive impairment.

ABSTRACT:

Introduction

This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI).

Methods

WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1-MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region-based and surface-based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region-based measures were also compared to published norms.

Results

Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface-based analyses revealed reduced CTX across frontal, temporal, and parietal lobes

SUBMITTER: Clouston SAP 

PROVIDER: S-EPMC7364857 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature