Collective effects of age, sex, genotype, and cognitive status on fitness outcomes.

ABSTRACT:

Introduction

Individuals with Alzheimer's disease (AD) broadly exhibit lower cardiorespiratory fitness (CRF) compared to cognitively healthy older adults. Other factors, such as increasing age and female sex, are also known to track with lower CRF levels. However, it is unclear how these factors together with AD diagnosis and genetic risk (apolipoprotein e4 ; APOE4) collectively affect CRF.

Methods

Our primary objective was to characterize the collective relationship of age, sex, APOE4 carrier status , and cognitive status (nondemented or AD) with two commonly reported CRF outcomes, VO₂ max and oxygen uptake efficiency slope (OUES). To interrogate the unique and combined effect of age, sex, APOE4, and cognitive status on CRF, we pooled multipl

SUBMITTER: Morris JK 

PROVIDER: S-EPMC7364859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature