[Association of WT1 rs16754 polymorphism with clinical features and prognosis in patients with acute myeloid leukemia].

ABSTRACT: Objective: To explore the relationship between WT1 rs16754 polymorphism and clinical features and prognosis in patients with acute myeloid leukemia(AML). Methods: Bone marrow samples of 115 newly diagnosed AML patients and peripheral blood samples of 177 healthy controls were collected from the Second Hospital of Shanxi Medical University from January 2010 to December 2013. The genotype of rs16754 was screened by high- resolution melting(HRM)and validated by direct sequencing. The association between the single nucleotide polymorphism(SNP)and the risk, clinical features, remission and survival state of AML patients was analyzed retrospectively. Results: This polymorphism was not associated with risk for AML(P=0.296), the GA/AA group and GG group had no significa

SUBMITTER: Xu J 

PROVIDER: S-EPMC7364874 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature