Wernicke-Kleist-Leonhard phenotypes 
of endogenous psychoses: a review of their validity
.

ABSTRACT: While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the re

SUBMITTER: Foucher JR 

PROVIDER: S-EPMC7365293 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature