The effect of repeated stimulated granulocyte donations on hematopoietic indexes in donors: a 24-year donor center experience.

ABSTRACT:

Background

Short- and long-term effects of mobilization regimens in hematopoietic stem cell and granulocyte donors have been well characterized. In this study, we examined the longitudinal hematopoietic changes related to repeat stimulated granulocyte donation.

Study design and methods

Complete blood counts for consecutive granulocyte donors between October 1994 and May 2017 were compared to unstimulated granulocyte donors. Plateletpheresis donors served as controls. The longitudinal change in precollection white blood cell (WBC) counts for these donor groups were modeled using a linear mixed-effects model. The investigated variables were granulocyte, lymphocyte, and monocyte counts and the granulocyte collection yield. Contrasts were performed to explore the effect of donat

SUBMITTER: Szymanski J 

PROVIDER: S-EPMC7365331 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature