Lung Function Trajectories Leading to Chronic Obstructive Pulmonary Disease as Predictors of Exacerbations and Mortality.

ABSTRACT: Rationale: Chronic obstructive pulmonary disease (COPD) can develop not only through a lung function trajectory dominated by an accelerated decline of FEV₁ from normal maximally attained FEV₁ in early adulthood (normal maximally attained FEV₁ trajectory) but also through a trajectory with FEV₁ below normal in early adulthood (low maximally attained FEV₁ trajectory).Objectives: To test whether the long-term risk of exacerbations and mortality differs between these two subtypes of COPD.Methods: The cohort included 1,170 young adults enrolled in the Copenhagen City Heart Study during the 1970s and 1980s. In 2001-2003, which served as the baseline for the present analyses, 79 participants had developed COPD through nor

SUBMITTER: Marott JL 

PROVIDER: S-EPMC7365378 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature