Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

ABSTRACT:

Purpose

Systemic inflammation and coronary microvascular dysfunction (CMD) may be causal drivers of heart failure with preserved ejection fraction (HFpEF). We tested the hypothesis that subclinical inflammation is associated with non-endothelial dependent CMD and diastolic dysfunction.

Methods

In a cross-sectional study of 336 women with angina but no flow limiting coronary artery stenosis (180 with diabetes) and 95 asymptomatic controls, blood samples were analysed for 90 biomarkers of which 34 were part of inflammatory pathways. CMD was assessed as coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography and defined as CFVR<2.5. We used E/e' as an indicator of diastolic function in age-adjusted linear regressions to assess correlations between biomar

SUBMITTER: Suhrs HE 

PROVIDER: S-EPMC7365405 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature