Different depths of sedation versus risk of delirium in adult mechanically ventilated patients: A systematic review and meta-analysis.

ABSTRACT:

Background

Delirium is multifactorial. This study aimed at determining the association between different depths of sedation and the risk of delirium in adult mechanically ventilated patients.

Methods

A systematic literature retrieval was conducted in databases including Cochrane Central Register of Controlled Trials, PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature for publications available till December 2019 without limitation in study type, and followed by a secondary retrieval for related literature. STATA15.1 and WinBugs 14.3 were used in statistical analyses for different sedation depths as the intervention. The main endpoint was delirium occurrence. Secondary endpoints were agitation-related adverse events and mortality.

Results

We inclu

SUBMITTER: Long L 

PROVIDER: S-EPMC7365415 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature