Unravelling the proteomic signature of extracellular vesicles released by drug-resistant Leishmania infantum parasites.

ABSTRACT: Leishmaniasis constitutes the 9th largest disease burden among all infectious diseases. Control of this disease is based on a short list of chemotherapeutic agents headed by pentavalent antimonials, followed by miltefosine and amphotericin B; drugs that are far from ideal due to host toxicity, elevated cost, limited access, and high rates of drug resistance. Knowing that the composition of extracellular vesicles (EVs) can vary according to the state of their parental cell, we hypothesized that EVs released by drug-resistant Leishmania infantum parasites could contain unique and differently enriched proteins depending on the drug-resistance mechanisms involved in the survival of their parental cell line. To assess this possibility, we studied EV production, size, morphology, and protein con

SUBMITTER: Douanne N 

PROVIDER: S-EPMC7365475 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature