Pre-Implantation Effects of Progesterone Administration on Ovarian Angiogenesis after Ovarian Stimulation: A Histological, Hormonal, and Molecular Analysis.

ABSTRACT: OBJECTIVE:Progesterone (P4) is known to directly affect ovarian tissue angiogenesis. The present study was designed to show how P4 affects ovarian angiogenesis in hormonal, histological, and molecular levels. METHODS:Fifteen adult female NMRI mice were divided into three groups: Control Group; Case Group I (ovarian stimulation alone); and Case Group II (ovarian stimulation followed by P4 administration). Blood and ovarian tissue samples were assessed for hormonal, histological, and molecular alterations. Gene expression for ovarian vascular endothelium growth factor (VEGF) and hypoxia-inducible factor-1 alpha (HIF-1α) was analyzed using real-time PCR. RESULTS:Ovarian hormone levels were increased in the case groups compared with the control group (p<0.05). Quantitative corpus luteum parame

SUBMITTER: Narimani L 

PROVIDER: S-EPMC7365533 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature